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. 2022 Mar 22;7(6):e153136. doi: 10.1172/jci.insight.153136

Figure 3. Increased number of CADM1+CD45+ cells within the pancreatic islet during T1D.

Figure 3

(A) Immunostaining of paraffin-embedded pancreata from individuals in the Non group for CADM1 (cyan), insulin (green), and GCG (red). Scale bar: 20 μm. (B) Immunostaining of paraffin-embedded pancreata from individuals in the Non, aAb+, and T1D groups for CADM1 (red) and CD45 (green). Scale bar: 50 μm. (C) Quantification of the number of CADM1+CD45+ cells within the islet periphery (n = 5 per group). (D) Quantification of the number of CD45+ adjacent to CADM1+ cells per area pancreas (n = 5 per group). One-way ANOVA was performed using GraphPad Prism, version 7, software for comparisons of 3 groups. Post hoc statistical analyses were performed using the Tukey multiple comparisons test. Results are presented as mean ± SEM. *P < 0.05; ***P < 0.001. ad., adjacent.