Figure 8. Increased number of CADM1⁺ cells adjacent to CD8⁺ T cells in the exocrine pancreas during T1D.

(A) Immunostaining of paraffin-embedded pancreata from individuals in the Non group for CADM1 (green), and pancreatic amylase (red). Scale bar: 30 μm. (B) Immunostaining of paraffin-embedded pancreata from the Non, aAb⁺, and T1D groups for CADM1 (green), and CD8 (red). Scale bar: 50 μm. (C) Quantification of the number of CD8⁺ cells adjacent to CADM1⁺ cells/mm² exocrine pancreas in pancreata of individuals in the Non, aAb⁺, and T1D groups (n = 5 per group). One-way ANOVA was performed using GraphPad Prism, version 7, software for comparisons of 3 groups. Post hoc statistical analyses were performed using Tukey’s multiple comparisons test. Results are presented as mean ± SEM. **P < 0.01; ***P < 0.001.