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. 2022 Mar 22;7(6):e152293. doi: 10.1172/jci.insight.152293

Figure 1. Integrative transcriptomic and kinase activity screen identifies WEE1 as a target in CIC-DUX4 sarcoma.

Figure 1

(A) Approach to identifying candidate kinases that regulate CIC-DUX4 sarcoma survival. Watson et al., 2019: ref. 19; Oyama et al., 2017: ref. 22. (B) Reactome pathway analysis identifies CIC-DUX4–dependent cell cycle and DNA replication pathways. (C) GSEA reveals cell cycle, DNA replication, and chromosome segregation at CIC-DUX4 targets. (D) PamGene array identifies functional kinases that regulate cell cycle and DNA replication in CIC-DUX4 cells. (E) Model of WEE1 inhibitory kinase motifs in CDK1 and CDK2. (F) Schematic of WEE1-regulated cell cycle control.