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. 2022 Apr 6;8(14):eabj8969. doi: 10.1126/sciadv.abj8969

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Fig. 3. — (A) Total effect of CRP on each psychiatric outcome considered. Each point represents the IV-exposure effect versus the IV-outcome effect. Trend lines are indicative of the slope of each MR method used. The outcomes plotted from left to right are AN, MDD, OCD, and SZ. (B) Direct effect of CRP in MVMR models—the three models contained the following phenotypes as additional exposures: circulating interleukin-6 (IL-6) and its receptor (IL-6R), body mass index (BMI), and IL-6R and BMI.