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. 2022 Apr 6;8(14):eabl5209. doi: 10.1126/sciadv.abl5209

Fig. 2. Wyeth/IL-15/5Flu increases the nonsynonymous SNP incidence and cumulative AF on the IAV genome.

Fig. 2.

(A) Total number of nonsynonymous SNPs and (B) cumulative AF arising in IAV gene sequences isolated from H1N1 days 3, 5, and 7 p.i. BALB/c mice vaccinated with PBS, S-QIIV, or Wyeth/IL-15/5Flu across all eight IAV genes (≥0.01 AF). Individual data points shown on box and whiskers plot, showing mean and upper and lower quartiles with minimum-maximum range. Statistical significance was determined by a Kruskal-Wallis test. False discovery rate (0.1) was determined by the original Benjamini and Hochberg method. * denotes significance between different vaccination groups at same time point, and # denotes significance between different time points within the same vaccination group. */#P ≤ 0.05, **/##P ≤ 0.01, ***/###P ≤ 0.001, and ####P ≤ 0.0001.