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. 2022 Apr 6;8(14):eabl5209. doi: 10.1126/sciadv.abl5209

Fig. 5. Wyeth/IL-15/5Flu–induced immune pressure does not induce widespread mutations within T cell epitope regions.

Fig. 5.

Fold change of nucleotide base diversity versus appropriate control PBS groups of known BALB/c T cell epitope and nonepitope regions in days 3, 5, and 7 p.i. in PBS, S-QIIV, and Wyeth/IL-15/5Flu in (A) HA, (B) NA, and (C) NP genes. Comparison between S-QIIV and Wyeth/IL-15/5Flu versus PBS within the same time point. Diversity measured in CD4+ and CD8+ T cell–depleted samples across (D) HA, (E) NA, and (F) NP. Comparison between nondepleted PBS and other conditions. Indicated statistical significance comparison between PBS and other conditions within the same time point (A to C) and depletion status (D to F) was determined by a Kruskal-Wallis test. False discovery rate (0.1) was determined by the original Benjamini and Hochberg method. Black annotation denotes significance between different vaccination groups at the same time point; red annotation denotes significance between different depletion status within the same vaccination group. *P ≤ 0.05, **P ≤ 0.01, and ***P ≤ 0.001.