Fig. 6. Mutations within conserved HA stem regions and beneficial PB2 adaptations can arise in Wyeth/IL-15/5Flu–vaccinated conditions.

Frequency of mutant (%) arising within H1N1-challenged PBS (n = 17)–, S-QIIV (n = 4)–, and Wyeth/IL-15/5Flu (n = 12)–vaccinated BALB/c mice at day 7 p.i. across two separate sequencing rounds within (A) at functional sites within the HA stem and (B) known mammalian-associated pathology mutations arising in PB2. Individual data points shown on violin plot.