(A) The baseline of the clinical study C characteristic and overall study outcome, medial margin of patient ID 183 positively scored by cancer diagnostic probe (CDP) which was reported as, (B) free margin in the frozen section, (C) but was confirmed as a focus of DCIS, intermediate grade on its reciprocal EMs by permanent pathology. (D) Lateral margin of patient ID 187 while frozen declared free margin on its reciprocal margin (EM‐), (E) but permanent pathology diagnosed margin involvement to ADH lesion on the same EM and confirmed CDP, receiver operating characteristic (ROC) diagram for (F) CDP and (G) frozen versus permanent pathology for total 450 EM and IM margins on 75 patients in the three clinical studies. (H) Area under the receiver operating characteristic (ROC) curve, confidence interval, p‐value, accuracy, sensitivity, specificity, positive predictive value, and negative predictive value of four clinical study