TABLE 1.
Patient characteristics comparison between the preoperative oncologic therapy and the upfront surgery patients
| n (%) | Preoperative oncologic therapy | Upfront surgery | p value |
|---|---|---|---|
| 93 | 291 | ||
| Gender | |||
| Female | 47 (50.5) | 145 (49.8) | |
| Male | 46 (49.5) | 146 (50.2) | 1.000 |
| Age (years) at operation | |||
| ≥65 | 45 (48.4) | 177 (60.8) | |
| <65 | 48 (51.6) | 114 (39.2) | 0.040 |
| Respiratory disease | |||
| Yes | 5 (5.4) | 21 (7.2) | |
| No | 88 (94.6) | 270 (92.8) | 0.641 |
| Cardiovascular disease | |||
| Yes | 11 (11.8) | 71 (24.4) | |
| No | 82 (88.2) | 220 (75.6) | 0.009 |
| Medication | |||
| ASA | |||
| Yes | 19 (20.4) | 67 (23.0) | |
| No | 74 (79.6) | 224 (77.0) | 0.669 |
| Statin | |||
| Yes | 19 (20.4) | 78 (26.8) | |
| No | 74 (79.6) | 213 (73.2) | 0.273 |
| Preoperative anticoagulant | |||
| Yes | 11 (11.8) | 23 (7.9) | |
| No | 82 (88.2) | 268 (92.1) | 0.290 |
| Postoperative anticoagulant <4 weeks a | 8 (8.6) | 58 (19.9) | 0.007 |
| Preoperative BMI ≥25 kg/m2 | |||
| Yes | 45 (48.4) | 155 (53.3) | |
| No | 48 (51.6) | 133 (45.7) | 0.404 |
| Missing b | 3 | ||
| Preoperative BMI ≥30 kg/m2 | |||
| Yes | 11 (11.8) | 44 (15.1) | |
| No | 82 (88.2) | 244 (83.8) | 0.498 |
| Missing b | 3 | ||
| Type of surgery | |||
| Pancreaticoduodenectomy | 84 (90.3) | 245 (84.2) | |
| Distal pancreatetctomy | 6 (6.5) | 37 (12.7) | |
| Total pancreatetctomy | 2 (2.2) | 9 (3.1) | 0.133 |
| Vascular reconstruction | |||
| Yes | 55 (59.1) | 83 (28.5) | |
| No | 38 (40.9) | 208 (71.5) | <0.001 |
| Grade | |||
| 1 | 14 (15.1) | 54 (18.6) | |
| 2 | 57 (61.3) | 187 (64.3) | |
| 3 | 20 (21.5) | 44 (15.1) | 0.024 |
| Missing c | 8 | ||
| Perineural invasion | |||
| Yes | 65 (70.7) | 230 (79.6) | |
| No | 27 (29.3) | 59 (20.4) | 0.040 |
| Missing c | 3 | ||
| Perivascular invasion | |||
| Yes | 30 (32.6) | 106 (36.7) | |
| No | 62 (67.4) | 183 (63.3) | 0.454 |
| Missing c | 3 | ||
| Stage | |||
| IA | 9 (9.7) | 21 (7.2) | |
| IB | 0 | 45 (15.5) | |
| IIA | 6 (6.5) | 6 (2.1) | |
| IIB | 32 (34.4) | 126 (43.3) | |
| III | 21 (22.6) | 91 (31.3) | 0.030 |
| Missing c | 3 | ||
| Resection margin | |||
| R0 | 71 (76.3) | 207 (71.9) | |
| R1 | 22 (23.7) | 81 (28.1) | 0.424 |
| Missing c | 3 | ||
| Adjuvant therapy | |||
| Yes | 72 (77.4) | 212 (72.9) | |
| No | 21 (22.6) | 79 (27.1) | 0.418 |
| Disease recurrence | |||
| Yes | 68 (73.1) | 231 (79.4) | |
| No | 25 (26.9) | 60 (20.6) | 0.251 |
Bold indicates statistical significance values (p < 0.05).
a
The routine modality of postoperative thromboprophylaxis before 2010 included anticoagulation while hospitalized.
b
Only weight, no height could be found.
c
Complete or nearly complete response to preoperative therapy. Few reports lacked data.