FIG. 2.

Effect of SCH27899 (30 or 60 MPK OD for 5 days) on intrapulmonary growth of L. pneumophila. A/J mice were administered CA (100 MPK) subcutaneously and inoculated IT with L. pneumophila (10⁵ CFU/mouse). At 24 h p.i., immunocompromised infected mice were administered SCH27899 (30 or 60 MPK i.v. OD) for 5 days or an equivalent volume of placebo for 5 days. Mice were subsequently humanely euthanized at 6 or 10 days p.i., lungs were excised and homogenized, and intrapulmonary L. pneumophila was quantified by culture of lung homogenates. Results represent the mean of bacteria in the lungs of 6 to 8 mice per time point. ∗, significantly less growth compared to similarly infected compromised untreated mice.