Table 2.

Allelic and genotypic distribution of TMPRSS2 polymorphisms

SNP	COVID-19, N (%)	Control, N (%)	Genetic model	OR (95%CI)	P-value
rs17854725 A>G
AA	72 (25.0)	92 (31.9)		1 [Reference]
AG	155 (53.8)	151 (52.4)	AG vs. AA	1.31 (0.90-1.92)	0.163
GG	61 (21.2)	45 (15.6)	GG vs. AA	2.92 (1.81-4.70)	<0.001*
HWE	0.185	0.189	Dominant	1.41 (0.98-2.03)	0.065
			Recessive	1.45 (0.95-2.22)	0.085
			Over dominant	1.06 (0.76-1.47)	0.738
A	299 (51.9)	335 (58.2)	Allelic	1 [Reference]
G	277 (48.1)	241 (41.8)	Allelic	1.29 (1.02-1.63)	0.033*
rs75603675 C>A
CC	99 (34.4)	85 (29.5)		1 [Reference]
CA	148 (51.4)	142 (49.3)	CA vs. CC	0.89 (0.62-1.30)	0.556
AA	41 (14.2)	61 (21.2)	AA vs. CC	0.58 (0.35-0.94)	0.027*
HWE	0.226	0.905	Dominant	0.80 (0.56-1.14)	0.211
			Recessive	0.62 (0.40-0.95)	0.029*
			Over dominant	1.09 (0.78-1.51)	0.617
C	346 (60.1)	312 (54.2)	Allelic	1 [Reference]
A	230 (39.9)	264 (45.8)	Allelic	0.79 (0.62-0.99)	0.043*
rs12329760 C>T
CC	61 (21.2)	90 (20.1)		1 [Reference]
CT	145 (50.3)	147 (51.0)	CT vs. CC	1.45 (0.98-2.17)	0.064
TT	82 (28.5)	51 (17.7)	TT vs. CC	2.37 (1.47-3.82)	<0.001*
HWE	0.834	0.498	Dominant	1.69 (1.16-2.47)	<0.006*
			Recessive	1.85 (1.24-2.75)	<0.002*
			Over dominant	0.97 (0.70-1.35)	0.868
C	267 (46.4)	327 (56.8)	Allelic	1 [Reference]
T	309 (53.6)	249 (43.2)	Allelic	1.52 (1.20-1.92)	<0.001*
rs4303795 A>G
AA	66 (22.9)	94 (32.6)		1 [Reference]
AG	159 (55.2)	138 (47.9)	AG vs. AA	1.64 (1.11-2.42)	0.012*
GG	63 (21.9)	56 (19.4)	GG vs. AA	1.60 (0.99-2.59)	0.053
HWE	0.076	0.675	Dominant	1.63 (1.13-2.36)	<0.009*
			Recessive	1.16 (0.77-1.74)	0.471
			Over dominant	1.34 (0.97-1.86)	0.080
A	291 (50.5)	326 (56.6)	Allelic	1 [Reference]
G	285 (49.5)	250 (43.4)	Allelic	1.28 (1.01-1.61)	0.039*

COVID-19, corona virus 2019; HWE, Hardy-Weinberg equilibrium; SNP, single-nucleotide polymorphism; CI, confidence interval; OR, odds ratio. P < 0.05 is considered statistically significant

Bold entities in all tables represent a p-value < 0.05