Fig. 3. Transferred matrix provides many raw components for tissue repair.
a, Mass-spectrometry analysis of matrisomal proteins derived from pulled-down NHS-EZ-Link marked organ surface ECM. Total matrix pools represent combined total amounts of original label and wound site at 24 hours p.i. Data represent mean ± s.d. One-way ANOVA was used for multiple comparisons testing, with Tukey’s test: *P < 0.05. b, Highlighted matrisomal protein groups derived from pulled down NHS-EZ-Link in wounds 24 hours p.i. from a. c, Gene ontology analysis of matrisomal genes via EnrichR webtool. Data represent the combined score. P values of Fisher’s exact tests are indicated. d,e, Matrisomal proteins classified on the basis of Uniprot entries in proregenerative and profibrotic categories. Data represent mean ± s.d. One-way ANOVA was used for multiple comparisons testing, with Tukey’s test: *P < 0.05. n = 6 biological replicates for peritoneum and liver, n = 5 biological replicates for cecum (all C57BL/6J WT mice); 3 independent experiments.