FIGURE 2.

Illustration of ZAP70 structure and signaling domains. (A) Cartoon of ZAP70 structural domains, including the N‐terminal and C‐terminal SH2 domains, interdomain A and B, and a kinase domain. Some of the tyrosine residues that are phosphorylated by LCK are also shown (red open circles). (B) A crystal structural model (left) or a schematic (right) of autoinhibited ZAP70. The key amino acid residues (illustrated by spheres) at which the mutations in ZAP70 described in this review are also labeled (W131, W163, Y315, Y319 and R360). The red and blue arrows indicate the key interaction among different structural domains of ZAP70 to maintain ZAP70 in the autoinhibitory state