Table 2.
Association of lower urinary tract symptoms (LUTS) severity at baseline with incident mobility limitation*.
| Age and site-Adjusted | Multivariable§ Adjusted | ||||
|---|---|---|---|---|---|
|
|
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| AUASI Score Range† | # Incident Limitation /Total (%) | Risk Ratio (95% CI)‡ | Risk Ratio (95% CI)‡ | P value | |
| Clinical LUTS Categories | |||||
| None/Mild | 0–7 | 173/1512 (11.4) | Ref. | Ref. | <0.001 |
| Moderate | 8–19 | 179/1045 (17.2) | 1.47 (1.21, 1.77) | 1.35 (1.12, 1.63) | |
| Severe | 20–35 | 42/159 (26.4) | 2.20 (1.64, 2.95) | 1.98 (1.48, 2.64) | |
|
| |||||
| Total AUASI | |||||
| Quartile 1 | 0–3 | 70/712 (9.8) | Ref. | Ref. | <0.001 |
| Quartile 2 | 4–7 | 103/800 (12.9) | 1.32 (0.99, 1.74) | 1.31 (0.99, 1.73) | |
| Quartile 3 | 8–12 | 88/608 (14.5) | 1.50 (1.12, 2.01) | 1.37 (1.03, 1.83) | |
| Quartile 4 | 13–35 | 133/596 (22.4) | 2.13 (1.64, 2.78) | 1.96 (1.51, 2.55) | |
|
| |||||
| Storage Subscore | |||||
| Tertile 1 | 0–3 | 135/1228 (11.0) | Ref. | Ref. | <0.001 |
| Tertile 2 | 4–6 | 127/848 (15.0) | 1.40 (1.12, 1.75) | 1.34 (1.08, 1.68) | |
| Tertile 3 | 7–15 | 132/640 (20.6) | 1.81 (1.46, 2.24) | 1.64 (1.32, 2.04) | |
|
| |||||
| Voiding Subscore | |||||
| Tertile 1 | 0–1 | 118/1108 (10.6) | Ref. | Ref. | <0.001 |
| Tertile 2 | 2–4 | 110/732 (15.0) | 1.37 (1.08, 1.74) | 1.33 (1.05, 1.68) | |
| Tertile 3 | 5–20 | 166/876 (19.0) | 1.69 (1.36, 2.09) | 1.56 (1.25, 1.93) | |
Defined as having any difficulty or inability for either walking 2–3 blocks or climbing 10 steps.
American Urological Association Symptom Index (AUASI) score range is 0 to 35 and equals the sum of 2 validated subscores based on symptom type: storage (urgency, frequency, nocturia) and voiding (intermittency, weak stream, straining, incomplete emptying). Higher score indicates more frequent symptoms. Total AUASI score was categorized using clinically validated thresholds for none/mild (0–7), moderate (8–19), and severe (20–35) LUTS and approximately into equal fourths (quartiles). Storage and voiding subscores were categorized approximately into equal thirds (tertiles) of the subscore distribution.
Risk ratios and 95% confidence intervals calculated using Poisson regression. P values calculated using the Wald test.
Adjusted for age, site, and history of myocardial infarction or angina, heart failure, hypertension, diabetes, chronic obstructive pulmonary disease, prostate cancer, and stroke or Parkinson’s disease.