Table 2.
Hydroxyurea use as an independent predictor of miscarriage or stillbirtha
| Covariate | N | Miscarriage or Stillbirth | N | Live birth | Odds ratio (95% CI) |
|---|---|---|---|---|---|
|
| |||||
| Pregnancy number greater than three, no. (%) | 434 | 89 (20.5%) | 1079 | 151 (13.9%) | 0.96 (0.60-1.50) |
|
| |||||
| Age at pregnancy, no. (%) | |||||
| - 26-30 | 397 | 84 (21.2%) | 1073 | 229 (21.3%) | 0.90 (0.61-1.30) |
| - 31-35 | 34 (8.6%) | 87 (8.1%) | 1.13 (0.66-1.91) | ||
| - 35+ | 15 (3.8%) | 26 (2.4%) | 0.87 (0.35-2.01) | ||
|
| |||||
| History of stillbirth or miscarriage, no. (%) | 434 | 170 (39.2%) | 1079 | 260 (24.1%) | 1.77 (1.25-2.48) |
|
| |||||
| Severe sickle genotype (Hb SS/Hb SBeta0/Hb SD/Hb SO/Hb SE), no. (%) | 432 | 321 (74.3%) | 1066 | 689 (64.6%) | 1.62 (1.09-2.41) |
|
| |||||
| Markers of Severity b | |||||
|
| |||||
| Number total visits in past year for acute pain, median (IQR), mean (std) | 362 | 3 (1-6), 6.8 (15.22) | 910 | 3 (1-7), 7.2 (13.84) | 0.98 (0.96-1.00) |
|
| |||||
| Hemoglobin (g/dL), median (IQR), mean (std) | 364 | 9.0 (7.8-10.1) 9.1 (1.68) | 920 | 9.2 (8.0-10.5) 9.3 (1.79) | 1.06 (0.95-1.17) |
|
| |||||
| Chronic kidney disease, no. (%) | 434 | 92 (21.2%) | 1079 | 164 (15.2%) | 1.47 (1.01-2.14) |
|
| |||||
| Pulmonary hypertension, no. (%) | 434 | 81 (18.7%) | 1079 | 200 (18.5%) | 0.89 (0.60-1.31) |
|
| |||||
| Predictor | |||||
|
| |||||
| Hydroxyurea use, no. (%) | |||||
| - at conception only | 387 | 23 (5.9%) | 989 | 74 (7.5%)) | 0.71 (0.37-1.29) |
| - at conception and during pregnancy | 58 (15.0%) | 67 (6.8%) | 2.21 (1.40-3.47) | ||
a
Excludes pregnancies that were current, missing an outcome, ended in elective abortion, or ended in stillbirth
b
Status of mother at enrollment
Odds ratios with p<.05 are bolded