Table 3.
Multivariate predictors of live birth outcomes
| Prematurity | |||||
|---|---|---|---|---|---|
|
| |||||
| Covariate | N | Premature | N | Full term | Odds ratio (95% CI) |
|
| |||||
| Pregnancy number >3, no. (%) | 384 | 65 (16.9%) | 669 | 79 (11.8%) | 0.96 (0.57-1.60) |
|
| |||||
| Age at pregnancy, no. (%) | |||||
| - 26-30 | 379 | 88 (23.2%) | 668 | 133 (19.9%) | 1.21 (0.82-1.79) |
| - 31-35 | 38 (10.0%) | 48 (7.2%) | 1.30 (0.71-2.36) | ||
| - 35+ | 9 (2.4%) | 14 (2.1%) | 1.17 (0.39-3.33) | ||
|
| |||||
| History of stillbirth or miscarriage, no. (%) | 384 | 105 (27.3%) | 669 | 147 (22.0%) | 1.64 (1.10-2.44) |
|
| |||||
| Severe sickle genotype (Hb SS/Hb SBeta0/Hb SD/Hb SO/Hb SE), no. (%) | 384 | 279 (72.7%) | 656 | 390 (59.5%) | 1.50 (0.99-2.29) |
|
| |||||
| Markers of Severity a | |||||
|
| |||||
| Number total visits in past year for acute pain, median (IQR), mean (std) | 332 | 3 (1-10) 7.7 (10.37) |
555 | 2 (1-6), 7.0 (15.55) |
1.00 (0.99-1.02) |
|
| |||||
| Hemoglobin (g/dL), median (IQR), mean (std) | 328 | 9.1 (7.9-10.3) 9.1 (1.71) |
570 | 9.4 (8.0-10.6) 9.4 (1.84) |
0.98 (0.87-1.09) |
|
| |||||
| Chronic kidney disease, no. (%) | 384 | 58 (15.1%) | 669 | 95 (14.2%) | 0.91 (0.58-1.40) |
|
| |||||
| Pulmonary hypertension, no. (%) | 384 | 87 (22.7%) | 669 | 104 (15.5) | 1.77 (1.20-2.62) |
|
| |||||
| Predictor | |||||
|
| |||||
| Hydroxyurea use, no. (%) | |||||
| - at conception only | 354 | 29 (8.2%) | >613 | 45 (7.3%) | 0.94 (0.52, 1.65) |
| - at conception and during pregnancy | 30 (8.5%) | 37 (6.0%) | 1.11 (0.61, 2.00) | ||
|
| |||||
| Birth weight < 5.5 pounds, among babies who are not premature | |||||
|
| |||||
| Covariate | N | Low birth weight | N | Normal birth weight | Odds ratio (95% CI) |
|
| |||||
| Pregnancy number greater than 3, no. (%) | 69 | 9 (13.0%) | 600 | 70 (11.7%) | 1.65 (0.60-4.27) |
|
| |||||
| Age at pregnancy, no. (%) | |||||
| - 26-30 | 69 | 12 (17.4%) | 599 | 121 (20.2%) | 0.85 (0.35-1.88) |
| - 31-35 | 3 (4.3%) | 45 (7.5%) | 0.69 (0.15-2.29) | ||
| - 35+ | 2 (2.9%) | 12 (2.0%) | 0.63 (0.03-4.36) | ||
|
| |||||
| History of stillbirth or miscarriage, no. (%) | 69 | 17 (24.6%) | 600 | 130 (21.7%) | 1.60 (0.70-3.45) |
|
| |||||
| Severe sickle genotype (Hb SS/Hb SBeta0/Hb SD/Hb SO/Hb SE), no. (%) | 69 | 46 (66.7%) | 599 | 344 (57.4%) | 1.09 (0.48-2.48) |
|
| |||||
| Markers of Severity a | |||||
|
| |||||
| Number of total visits in past year for acute pain, median (IQR), mean (std) | 59 | 3 (1-8), 9.1 (18.7) |
496 | 2 (1-6), 6.7 (15.1) |
1.00 (0.97-1.02) |
|
| |||||
| Hemoglobin (g/dL), median (IQR), mean (std) | 61 | 8.8 (7.2-10.5), 9.1 (1.85) |
509 | 9.5 (8.0-10.7), 9.5 (1.84) |
0.93 (0.75-1.14) |
|
| |||||
| Chronic kidney disease, no. (%) | 69 | 11 (15.9%) | 600 | 84 (14.0%) | 1.11 (0.44-2.52) |
|
| |||||
| Pulmonary hypertension, no. (%) | 69 | 14 (20.3%) | 598 | 90 (15.0%) | 1.90 (0.84-4.02) |
|
| |||||
| Predictor | |||||
|
| |||||
| Hydroxyurea use no. (%) | |||||
| - at conception only | 59 | 4 (6.8%) | 554 | 41 (7.4%)) | 0.94 (0.22-2.87) |
| - at conception and during pregnancy | 7 (11.9%) | 30 (5.4%) | 2.98 (1.09-7.38) | ||
|
| |||||
| Other serious medical problem in infant | |||||
|
| |||||
| Covariate | N | Medical problem | N | No problem | Odds ratio (95% CI) |
|
| |||||
| Pregnancy number greater than 3, no. (%) | 53 | 14 (26.4%) | 995 | 128 (12.9%) | 1.50 (0.56-3.74) |
|
| |||||
| Age at pregnancy, no. (%) | |||||
| - 26-30 | 52 | 12 (23.1%) | 990 | 207 (20.9%) | 0.65 (0.23-1.62) |
| - 31-35 | 5 (9.6%) | 81 (8.2%) | 0.53 (0.08-2.03) | ||
| - 35+ | 2 (3.8%) | 21 (2.1%) | 2.18 (0.30-9.94) | ||
|
| |||||
| History of stillbirth or miscarriage, no. (%) | 53 | 22 (41.5%) | 995 | 227 (22.8%) | 1.90 (0.80-4.27) |
|
| |||||
| Severe sickle genotype (Hb SS/Hb SBeta0/Hb SD/Hb SO/Hb SE), no. (%) | 53 | 34 (64.2%) | 982 | 634 (64.6%) | 1.05 (0.41-2.73) |
|
| |||||
| Markers of Severity a | |||||
|
| |||||
| Number total visits in past year for acute pain, median (IQR), mean (std) | 43 | 3 (1-8), 7.9 (10.92) |
839 | 3 (1-7), 7.2 (13.83) |
1.01 (0.98-1.03) |
|
| |||||
| Hemoglobin (g/dL), median (IQR), mean (std) | 41 | 8.9 (8.0-11.1), 9.5 (2.04) |
852 | 9.2 (8.0-10.5), 9.3 (1.79) |
1.06 (0.87-1.28) |
|
| |||||
| Chronic kidney disease, no. (%) | 53 | 9 (17.0%) | 995 | 146 (14.7%) | 0.93 (0.30-2.37) |
|
| |||||
| Pulmonary hypertension, no. (%) | 53 | 10 (18.9%) | 995 | 181 (18.2%) | 0.94 (0.33-2.27) |
|
| |||||
| Predictor | |||||
|
| |||||
| Hydroxyurea use no. (%) | |||||
| - at conception only | 48 | 2 (4.2%) | 916 | 71 (7.8%) | 0.84 (0.13-2.95) |
| - at conception and during pregnancy | 5 (10.4%) | 61 (6.7%) | 1.33 (0.31-4.01) | ||
a
Status of mother at enrollment
Odds ratios with p<.05 are bolded