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Cytoplasmic peptidoglycan precursors synthesized by E. faecium BM4416a
| Culture | % of peptidoglycan precursors
|
|||
|---|---|---|---|---|
| UDP-MurNAc-tripeptide | UDP-MurNAc-tetrapeptide | UDP-MurNAc-pentapeptide | UDP-MurNAc-pentadepsipeptide | |
| Uninduced | 7 | 24 | <1 | 69 |
| Induced (vancomycin, 4 μg/ml) | 11 | 24 | <1 | 65 |
Peptidoglycan synthesis was inhibited by addition of ramoplanin to the cultures for 20 min. The individual precursors were characterized by amino acid analysis and mass spectroscopy.
