Table 4.
Diary-based migraine frequency, pain score and days with pain medication in patients with migraine existing before start with combined hormonal contraception (CHC) (group 1) and women whose migraine started after having initiated CHC (group 2)
| Migraine days | p** | Days with pain medication | p** | Mean Pain score | p** | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| All | Group 1 | Group 2 | Group 1 | Group 2 | Group 1 | Group 2 | ||||||
| Complete cycle (28 days) | 4.1 ± 2.8 | 4.5 ± 2.2 | 3.8 ± 3.2 | 0.07 | 3.2 ± 3.0 | 3.5 ± 2.6 | 3.0 ± 3.3 | 0.15 | 8.3 ± 7.7 | 9.0 ± 4.5 | 7.7 ± 9.5 | 0.03 |
| Week 1 (mean SD) Hormone-free interval | 2.1 ± 1.6* | 2.4 ± 1.4* | 1.9 ± 1.7* | 0.06 | 1.6 ± 1.3* | 1.7 ± 1.3* | 1.5 ± 1.3* | 0.35 | 4.4 ± 3.3* | 5.0 ± 2.9* | 3.8 ± 3.6* | 0.02 |
| Weekly mean of weeks 2–4 (mean SD) Pill use | 0.7 ± 1.0 | 0.7 ± 0.5 | 0.6 ± 0.9 | 0.34 | 0.6 ± 0.8 | 0.6 ± 0.6 | 0.5 ± 1.0 | 0.53 | 1.3 ± 2.2 | 1.3 ± 1.2 | 1.3 ± 2.8 | 0.43 |
*p < 0.001 week 1 compared to mean of weeks 2–4
**p between groups