Fig. 3.

OXTR methylation over time. Methylation of OXTR exons 1 and 2 in the different groups at both time points. Methylation values are provided as estimated marginal means and standard errors derived from the mixed linear modelling (see “Materials and Methods” and “Results” sections). A In the group comparison analyzing MDD patients vs. controls, OXTR exon 1 methylation is significantly lower in MDD patients while OXTR methylation levels are stable over time. B Comparing three groups (controls, MDD patients remitting under therapy, and MDD patients not remitting under therapy), remitters show lowest OXTR methylation in exon 1 and highest OXTR methylation in exon 2. No significant time point × group interaction occurred. Further details are summarized in the “Results” section