Table 7.

OXTR DNA methylation over time depending on therapy outcome

	Whole fragment		Exon 1		Exon 2
	F(42.6300)	P	F(35.5258)	P	F(6.1040)	P
Intercept	5869.25	< 0.001	4545.41	< 0.001	1353.56	< 0.001
CpG position	146.07	< 0.001	131.78	< 0.001	181.72	< 0.001
Time point	0.18	0.67	0.02	0.89	0.32	0.57
Group (three levels)	7.77	< 0.001	19.85	< 0.001	7.16	0.001
CpG * time point	0.67	0.951	0.84	0.74	0.23	0.97
CpG * group	1.79	< 0.001	1.23	0.09	1.62	0.08
Time point * group	0.38	0.68	0.71	0.49	0.45	0.64
N = 84

Analyses were carried out for the whole OXTR fragment and exons 1 and 2 separately. Three-level group variable includes controls, patients remitting under treatment, and patients not remitting. P-values of the post hoc tests for group are provided in Fig. 4