Table 8.

Association of oxytocin plasma levels and OXTR exon 2 methylation at baseline

Parameter	Estimate	SE	95% CI		P
			LL	UL
(a) Two-level grouping variable (patients vs. controls)
Constant	353.15	34.80	283.89	422.41	< 0.001
Group	−96.09	47.14	−189.91	−2.27	0.05
Mean exon 2 methylation	−350.18	386.23	−1118.80	418.43	0.37
Group * methylation	1202.63	507.96	191.75	2213.51	0.02
(b) Three-level grouping variable (controls, remitters, non-remitters)
Constant	353.15	34.90	283.65	422.65	< 0.001
Group = non-remitters	−60.97	54.73	−169.94	48.01	0.27
Group = remitters	−155.80	64.95	−285.14	−26.47	0.02
Group = controls	0a
Mean exon 2 methylation	−350.18	387.32	−1121.44	421.07	0.37
Group = non-remitters * methylation	740.34	617.68	−489.61	1970.29	0.02
Group = remitters * methylation	1777.02	624.60	533.29	3020.75	0.006
Group = controls * methylation	0a

^aRedundant, set to zero