Fig. 5.

SOX6 is the downstream target of STC2. a GSEA analysis of STC2 knockdown RNA-seq data. The signature was defined by genes with significant expression changes. b The effects of STC2 knockdown and ITGB2 rescue were detected by Western blotting. c qRT-PCR analysis of SOX-related genes in STC2 silencing and its control cell lines. Data are shown as mean ± SD. Significance was calculated using Student’s t test. *p < 0.01. d Compared with control group, STC2 knockdown affected the activity of HK2/GLUT1/MMP3 promoter activity in 6-10B and CNE1 cells. e Immunofluorescence staining showed the inhibition of SOX6 expression caused by STC2 could be rescued by ITGB2 overexpression