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. 2022 Apr 6;13:1870. doi: 10.1038/s41467-022-29512-0

Fig. 2. The prevalence of autoantibodies against glucokinase and citrullinated glucokinase in both murine and human models of T1D.

Fig. 2

a rhGK and PAD-rhGK (1 µg per lane) were subjected to electrophoresis and followed by immunoblot with rabbit anti-GK as positive control (+) and sera from 16-week-old B10.BR and NOD mice, respectively (lanes 1–6). b–c The serum levels of anti-GK and anti-citrullinated GK from NOD mice and control mice (b) and from patients with T1D and healthy subjects (c) were measured by ELISA (as described in Methods). The number of samples analyzed is indicated at the bottom of each group and the error bars indicated SD of mean. Statistical analysis was performed using Student’s t-test.