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. 2022 Apr 6;5:326. doi: 10.1038/s42003-022-03251-w

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Phosphorylation of ASK1 was up-regulated by GSTM2 KD and down-regulated by GSTM2 OE. c, d p-p38 and p-JNK levels were up-regulated by GSTM2 knockdown (KD) and down-regulated by GSTM2 OE. e GSTM2 OE down-regulated ASK1-p38/JNK signalling in the presence of palmitic acid treatment. f GSTM2 interacted with ASK1 by co-IP detection. g GSTM2 C-terminal, not N-terminal, down-regulated ASK1 activity. h SREBF1 and PLIN2 expression level was up-regulated by GSTM2 KD. i SREBF1 and PLIN2 expression level was down-regulated by GSTM2 OE. j More LDs were observed in cells with SREBF1 or PLIN2 overexpression. k Statistical analysis of number of LDs in cells with SREBF1 or PLIN2 overexpression. l Expression levels of SREBF1 and PLIN2 were down-regulated by GS-4997 treatment (ASK1 activity inhibitor). m Statistical analysis of number of LDs in shGSTM2 cells and shGSTM2 cells treated with GS-4997. n WB detection of SREBF1 and PLIN2 in shGSTM2 cells treated with PA. o WB detection of SREBF1 and PLIN2 in shGSTM2 cells treated with GS-4997. Bar, 10 μm.