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. 2022 Apr 6;12:5772. doi: 10.1038/s41598-022-09798-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Cluster specific gene ontology pathway analysis. (A) Result from gene ontology pathway analysis. Genes associated with a hypomethylated DMR in cluster 1 or cluster 2 and located in a promoter and/or TSS region, were used as input for GO pathway analysis. The most significant biological pathways found for cluster 1 and cluster 2, respectively are shown. Metabolic pathways were identified in cluster 2, indicating hepatocytes (HCs). For cluster 1 the identified GO pathways did not reveal a specific cell type (B) A subset of the genes with DMRs in promoter regions. The DNA methylation status of the DMRs in each respective cluster are shown (low methylation = blue, high methylation = red).