Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Apr 6;12:5776. doi: 10.1038/s41598-022-09765-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Coordinated up-regulation of TE transcription is observed in a subset of DAC treated KG1a cells. TE families with altered expression between untreated (red) and DAC treated (blue) KG1a cells were identified by differential expression analysis using DEseq2. The heatmap shows the relative expression of all TEs from significant families (adjusted p < 0.05) following normalisation by variance stabilisation transformation (vst) (DESeq2) and mean centering. Both rows (TEs) and columns (cells) are clustered by Euclidean distance. Global DNA methylation percentages for each cell are indicated (green scale at top) and selected TE families are highlighted (left). In total, 11 TE families reached the significance threshold (Family:Class; acro:Satellite, ERV1:LTR, ERVK:LTR, L1:LINE, Alu:SINE, ERVL:LTR, ERVL-MaLR:LTR, TcMar-Tigger:DNA, hAT-Charlie:DNA, MIR:SINE, L2:LINE), corresponding to 834 TE elements. A sub-cluster of mostly DAC treated cells (left) have high expression of TEs.