FIG. 1.

(A) Median time-kill curves of Streptococcus pneumoniae and Staphylococcus aureus following incubation with centrifuged (▴) and uncentrifuged (■) SBF sampled before drug administration and following incubation with centrifuged (▵) and uncentrifuged (□) SBF sampled 5 h after drug intake. In addition, kill curves with medium containing the MBC of levofloxacin (○) are shown. Error bars indicate SD. (B) Killing of Streptococcus pneumoniae and Staphylococcus aureus 2 h after incubation with uncentrifuged and centrifuged SBF. Asterisks indicate statistically significant differences (P < 0.05). Error bars indicate SD.