TABLE 5.

Principal findings of other model studies included in this review.

	Animal model	Author	Specie	Sex	Age	Behavior characterization	Methods	Analysis	Results	Rescue experiments	Reelin alteration
Other models	Reelin injection	Ishii et al., 2015a	Mouse	Male	6–7-week-old	PPI, novel object recognition.	Reelin injection in lateral ventricle of mouse and PCP (1 mg/kg) 30 min before behavior test	Immunohistochemistry (VLDLR, CaMKII and PV). Behavioral characterization.	Reelin injection prevents PCP- induced behavioral phenotypes, increases dendritic spines density and synaptic plasticity, and improves memory and spatial learning.	Reelin injection	Reelin injection
		Ishii et al., 2015b	Mouse	Male	P14.5, 7-month-old	Y- maze, three chamber test (P14.5)	Mice with focal heterotopias in somatosensory cortex	In situ hybridation. Behavioral characterization.	Impaired spatial working memory and low competitive dominant behavior. Decreased immediate early gene expression.		No differences
		Sawahata et al., 2021	Mouse	Male	7–9-week-old	NOR, PPI, y-maze.	Reelin injection in mPFC of MK-801 model (0,15 mg/kg 30 min before behavior test).	Immunohistochemistry (c-Fos positive cells in mPFC). Behavioral characterization.	Reelin injection prevents MK- 801-induced impairment of recognition memory. No effect of treatment in sensory-motor gating or short term memory defects. Reelin treatment reduced number of c-Fos positive cells to control levels in mPFC.	Reelin injection	Reelin injection
	High fat diet	Roberts et al., 2019	Mouse	Male	12–24-week-old		Mouse with high fat diet (12–16 weeks)	qPCR and western blot (ApoER2 and VLDLR). ISH (RELN, VLDLR and ApoER2).	Reduced expression of ApoER2 and VLDLR and increased levels of reelin protein in hypothalamus.		↑ reelin expression
	Reelin antisense	Brosda et al., 2011	Rat	Male	P43, p93	PPI, startle reflex, working memory, novel object recognition, locomotor activity.	Reelin antisense (knock down) in PFC of rats	Western blot (reelin in mPFC). Behavioral characterization.	Impairment of PPI, spatial memory and novel object recognition. Selective alteration of mPFC. Low reelin protein expression		↓ reelin expression