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. 2022 Mar 24;13:843322. doi: 10.3389/fimmu.2022.843322

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Copyright © 2022 Wang, Zhang, Zhai, Li, Shi and Ying

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Cell–cell communication network in OSCC TIME. (A) Cancer-associated fibroblasts (CAFs) of OSCC are annotated as inflammatory cancer-associated fibroblasts (iCAFs) and myo-cancer-associated fibroblasts (mCAFs) according to their characteristic marker genes. (B) Enriched KEGG pathways of upregulated genes in iCAFs and mCAFs. (C) Percentage content of MCAF and ICAF in metastatic and primary sites. (D) Expression levels of CXCL12 in various types of cells. (E) Correlation analysis between iCAFs content, CXCL12 expression, and M2 macrophages infiltration level. (F) Heatmap showing the number of potential ligand–receptor pairs between all types of cells predicted by CellphoneDB2. (G) Using bubble plots to exhibit ligand–receptor pairs of growth factors and cytokines between iCAFs/mCAFs and other cell groups. (H) Predicted cell–cell communication network centered on iCAFs and mCAFs. ****P < 0.0001.