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In vitro and in vivo safety evaluation of RSL-3@PVs. (A) Relative cell viability of PANC-2, PANC-1, MIA PaCa-2 at different concentrations. (B) Liver and kidney function (AST, ALT and BUN) in serum of healthy ICR mice after treatment with the indicated formulations. (C) Representative images of major organs from mice after treatment with the indicated formulations. Scale bars, 100 μm. Error bars represent the mean ± s.d. One-way ANOVA was used for multiple comparisons, ns P > 0.05.
