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. 2022 Mar 24;13:824468. doi: 10.3389/fpsyt.2022.824468

TABLE 2.

Predictors of treatment efficacy after pain and relief phases (Results of generalized linear models, GLM).

Treatment efficacy after pain phase (R2 = 0.17)
Predictors Estimates Std. Beta CI Std. CI t p df
(Intercept) 69.76 –0.00 23.6–116.0 –0.31–0.31 2.96 0.006 33
Pre-treatment expectation (VAS) 0.25 0.17 –0.30–0.80 –0.20–0.53 0.89 0.38 33
Perceived intensity for pain phase (VAS) –0.13 –0.13 –0.45–0.20 –0.48–0.21 –0.76 0.45 33
Stimulus intensity for pain phase (mmHg) –0.37 –0.21 –1.01–0.27 –0.58–0.16 –1.13 0.27 33
Tension after pain phase (VAS) 0.11 0.18 –0.10–0.32 –0.16–0.52 1.05 0.30 33
Duration of medication reminder communication (minutes) –0.85 –0.14 –3.03–1.32 –0.49–0.21 –0.77 0.45 33

Treatment efficacy after relief phase (R2 = 0.54)

Predictors Estimates Std. Beta CI Std. CI t p df

(Intercept) –6.06 –0.00 –46.5–34.4 –0.23–0.23 –0.29 0.77 32
Pre-treatment expectation (VAS) 0.53 0.35 0.09–0.97 0.06–0.64 2.37 0.024 32
Treatment efficacy rating for pain phase (VAS) 0.59 0.59 0.33–0.86 0.33–0.86 4.35 <0.001 32
Perceived intensity for relief phase (VAS) 0.06 0.06 –0.27–0.39 –0.28–0.40 0.35 0.73 32
Stimulus intensity for relief phase (mmHg) 0.17 0.10 –0.35–0.68 –0.20–0.39 0.64 0.53 32
Tension after relief phase (VAS) –0.10 –0.15 -0.31–0.12 –0.49–0.19 –0.88 0.39 32
Duration of medication reminder communication (minutes) –0.06 –0.01 –1.84–1.71 –0.30–0.28 –0.07 0.94 32

Separate generalized linear models (GLMs) with pre-treatment expectation as exploratory and treatment efficacy ratings as response variables were calculated for the pain and pain relief phases, respectively, in all positively instructed volunteers (N = 40, placebo group). CI, confidence interval; df, degree of freedom; Std., Standardized; t, t value; VAS, visual analog scale. Significant p-values are printed in bold.