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. 2022 Apr 6;13:1855. doi: 10.1038/s41467-022-29514-y

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Fig. 6 — The rs2280381-containing region forms a gene-loop with the IRF8 promoter region. The rs2280381 T risk allele has lower PU.1-binding affinity than the non-risk C allele, which results in the reduced expression of AC092723.1, upregulation of methylation levels at IRF8 promoter, and the decreased expression of IRF8 contributing to SLE risk. DHS DNase I hypersensitive site.