Table 1.
Effects of microRNAs on immune cells in rheumatoid arthritis.
| miRNA | miRNA trends | Targets | Targets trends | Location | Functions | Reference |
|---|---|---|---|---|---|---|
| miR-671 | ↓ | CDR1 | ↑ | PBMC | / | (40) |
| miR-7 | ↓ | mTOR | ↑ | |||
| miR-29b | ↑ | HBP1 | ↑ | (73) | ||
| miR-99b-5p | ↑ | mTOR | ↑ | T cell | inhibiting T cell apoptosis, promoting T cell proliferation, inflammatory response | (41) |
| RASSF4 | ||||||
| miR-146a | ↑ | FAF1 | ↑ | inhibiting apoptosis of T cell and RA progression | (35) | |
| IL-17 | ↑ | (74) | ||||
| miR-26 | ↑ | / | / | / | (35, 74) | |
| miR-let-7a | ↑ | |||||
| miR-146b | ↑ | |||||
| miR-150 | ↑ | |||||
| miR-155 | ↑ | |||||
| miR-363 | ↓ | |||||
| miR-498 | ↓ | |||||
| miR-233 | ↑ | (75) | ||||
| miR-20a | ↓ | NLRP3 | ↑ | Treg/Th17 | the imbalance of Th17/Treg cells | (77) |
| miR-21 | ↓ | STAT3 | ↑ | (78, 79) | ||
| STAT5 | ↓ | |||||
| miR-210 | ↓ | HIF-1 | ↑ | (80) | ||
| miR-146a | ↓ | STAT1 | ↑ | Treg cells | / | (38) |
| miR-6089 | ↓ | TLR4 | ↑ | macrophages | exacerbates inflammation via the TLR4/NF-κB pathway | (81) |
| miR-33 | ↑ | NLRP3 | ↑ | / | (82) | |
| caspase-1 |