Fig. 4. Relaxant (A) and contractile (B) response to acetylcholine (3 µM) or phenylephrine (100 µM), respectively, on isolated rabbit corpora cavernosa strips from eugonadal rabbit fed a regular diet (RD) and treated with (RD+T) or not with supraphysiological concentration of testosterone (T). Results in rabbit treated as before but performing physical exercise (PhyEx) are also showed (RD+PhyEx and RD+T+PhyEx). Level of significance upon Kruskal–Wallis and post-hoc Mann–Whitney analyses is also indicated, along with number of observations. Panel (C) shows frequency-dependent erectile response of eugonadal rat treated or not with a supraphysiological dose of T. Erection was elicited by electrical stimulation (2.5 V, 5 msec, 30 s) of the cavernous nerve at varying stimulation frequency (1–32 Hz). Erectile function was quantified by intracavernous pressure/mean arterial pressure (ICP/MAP)×100 in the indicated numer of rats. *Outlier.
