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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Drug Deliv Transl Res. 2021 Oct 30;11(6):2448–2467. doi: 10.1007/s13346-021-01079-1

Figure 2: Convection enhanced delivery of therapeutic cells.

Figure 2:

Briefly, a catheter is surgically placed in the cranium to delivery therapeutic cells via convection supplied by a pressure source. Cells travel along the convection front, seeding the tumor. CED allows for directly bypassing the BBB, allowing for minimal systemic exposure to potentially toxic therapy, and increasing therapeutic exposure. However, CED is limited in that the small distribution volume is often not sufficient to cover the entire tumor, and comes with surgical risks including backflow along the catheter and tissue rupture. In order to maximize tumor coverage and therapeutic effect of this delivery modality, mathematical modeling may be employed to predict both coverage volume and the therapeutic mechanism of the cells.