TABLE 2.
Correlation analysis between ITGAL and related genes and markers of immune cells in Tumor Immune Estimation Resource (TIMER2.0).
| Description | Gene markers | STAD | |||
|---|---|---|---|---|---|
| None | Purity | ||||
| Cor | p | Cor | p | ||
| CD8+ T cell | CD8A | 0.845 | *** | 0.83 | *** |
| CD8B | 0.658 | *** | 0.64 | *** | |
| T cell (general) | CD3D | 0.873 | *** | 0.856 | *** |
| CD3E | 0.904 | *** | 0.894 | *** | |
| CD2 | 0.691 | *** | 0.88 | *** | |
| B cell | CD19 | 0.893 | *** | - | - |
| CD79A | 0.711 | *** | 0.683 | *** | |
| Monocyte | CD86 | 0.75 | *** | 0.733 | *** |
| CD115 (CSF1R) | 0.712 | *** | 0.716 | *** | |
| TAM | CCL2 | 0.414 | *** | 0.373 | *** |
| CD68 | 0.498 | *** | 0.49 | *** | |
| IL10 | 0.556 | *** | 0.53 | *** | |
| M1 Macrophage | INOS (NOS2) | 0.146 | * | 0.139 | * |
| IRF5 | 0.42 | *** | 0.399 | *** | |
| COX2(PTGS2) | −0.053 | 0.28 | −0.098 | 0.0561 | |
| M2 Macrophage | CD163 | 0.631 | *** | 0.626 | *** |
| VSIG4 | 0.549 | *** | 0.546 | *** | |
| MS4A4A | 0.669 | *** | 0.657 | *** | |
| Neutrophils | CD66b | −0.001 | 0.978 | −0.009 | 0.859 |
| CD11b (ITGAM) | 0.666 | *** | 0.656 | *** | |
| CCR7 | 0.784 | *** | 0.76 | *** | |
| Natural killer cell | KIR2DL1 | 0.339 | *** | 0.312 | *** |
| KIR2DL3 | 0.31 | *** | 0.269 | *** | |
| KIR2DL4 | 0.416 | *** | 0.382 | *** | |
| KIR3DL1 | 0.39 | *** | 0.382 | *** | |
| KIR3DL2 | 0.481 | *** | 0.45 | *** | |
| KIR3DL3 | 0.137 | * | 0.153 | * | |
| KIR2DS4 | 0.341 | *** | 0.321 | *** | |
| Dendritic cell | HLA-DPB1 | 0.791 | *** | 0.771 | *** |
| HLA-DQB1 | 0.616 | *** | 0.57 | *** | |
| HLA-DRA | 0.733 | *** | 0.71 | *** | |
| HLA-DPA1 | 0.722 | *** | 0.696 | *** | |
| BDCA-1(CD1C) | 0.616 | *** | 0.583 | *** | |
| BDCA-4(NRP1) | 0.469 | *** | 0.447 | *** | |
| CD11c (ITGAX) | 0.718 | *** | 0.713 | *** | |
| Th1 | T -bet (TBX21) | 0.882 | *** | 0.877 | *** |
| STAT4 | 0.83 | *** | 0.826 | *** | |
| STAT1 | 0.527 | *** | 0.533 | *** | |
| IFN-γ (IFNG) | 0.605 | *** | 0.59 | *** | |
| TNF-α (TNF) | 0.356 | *** | 0.286 | *** | |
| Th2 | GATA3 | 0.64 | *** | 0.616 | *** |
| STAT6 | 0.287 | *** | 0.313 | *** | |
| STAT5A | 0.631 | *** | 0.622 | *** | |
| IL13 | 0.183 | ** | 0.173 | ** | |
| Tfh | BCL6 | 0.324 | *** | 0.301 | *** |
| IL21 | 0.531 | *** | 0.511 | *** | |
| Th17 | STAT3 | 0.411 | *** | 0.416 | *** |
| IL17A | 0.1 | 0.0417 | 0.095 | 0.0651 | |
| Treg | FOXP3 | 0.801 | *** | 0.779 | *** |
| CCR8 | 0.738 | *** | 0.733 | *** | |
| STAT5B | 0.485 | *** | 0.509 | *** | |
| TGFβ (TGFB1) | 0.499 | *** | 0.485 | *** | |
| T cell exhaustion | PD-1 (PDCD1) | 0.799 | *** | 0.78 | *** |
| PDL1(PDCD1LG2) | 0.757 | *** | 0.745 | *** | |
| CTLA4 | 0.702 | *** | 0.668 | *** | |
| LAG3 | 0.735 | *** | 0.718 | *** | |
| TIM-3 (HAVCR2) | 0.751 | *** | 0.74 | *** | |
| GZMB | 0.562 | *** | 0.523 | *** | |
Note. STAD, stomach adenocarcinoma; TAM, tumor-associated macrophage; Th, T helper cell; Tfh, Follicular helper T cell; Treg, regulatory T cell; Cor, R value of Spearman’s correlation; None, correlation without adjustment; Purity; correlation adjusted by purity.
*p < 0.01; **p < 0.001; ***p < 0.0001.