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. 2022 Mar 24;13:866170. doi: 10.3389/fendo.2022.866170

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Copyright © 2022 Mindler, Stauffer, Kranzl, Penzkofer, Ganger, Radler, Haeusler and Raimann

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Femoral torsion (MRI measurement) observed in the XLH cohort (yellow dots represent each femur) with Burosumab therapy compared to the norm group (grey). 8/14 femora showed reduced antetorsion, respectively retrotorsion. Radiographic norm group values (+-1SD) were obtained from Fabry et al. (17). (B) Tibial torsion (MRI) was assessed in a XLH population undergoing Burosumab therapy (yellow dots represent each tibia). 9/14 legs showed reduced external tibial torsion. Clinical reference values (+-2SD) obtained by Staheli et al. (18) are shown by the grey area.