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Wrist and knee radiographs obtained before therapy onset (A, C) and at the one-year follow-up show resolution of rickets (B, D) in case 6. Linear growth, onset of treatment and thelarche (B2) are marked on the Austrian reference growth chart for girls (E). The course of relevant biochemical parameters shows increase of serum phosphate and normalization of ALP with onset of Burosumab treatment around 10 years of age (F).
