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Schematic representation of the PI3K/Akt/mTOR pathway and its related inhibitors in solid tumors. The activation of the PI3K/Akt/mTOR pathway is associated with cell proliferation, autophagy, apoptosis, angiogenesis, EMT, and chemoresistance in solid tumors. GF, growth factor; EMT, epithelial-to-mesenchymal transition; RTK, tyrosine kinase receptor.
