Table 2.
Genetic alterations of the PIK3CA, mTOR, PTEN, AKT1, AKT2, and AKT3 genes in human cancers.
| PIK3CA | |||
|---|---|---|---|
| Cancer Type | Number of Cases | Mutation Frequency | Amplification Frequency |
| Endometrial Carcinoma | 586 | 44.54% | 4.10% |
| Cervical Squamous Cell Carcinoma | 251 | 22.71% | 11.55% |
| Invasive Breast Carcinoma | 1084 | 30.72% | 1.85% |
| Head and Neck Squamous Cell Carcinoma | 523 | 13.58% | 11.85% |
| Colorectal Adenocarcinoma | 594 | 24.75% | – |
| Bladder Urothelial Carcinoma | 411 | 20.44% | 2.68% |
| Non-Small Cell Lung Cancer | 1053 | 5.41% | 15.95% |
| Ovarian Epithelial Tumor | 584 | 0.86% | 19.35% |
| Esophagogastric Adenocarcinoma | 514 | 14.20% | 5.06% |
| Diffuse Glioma | 513 | 8.19% | 0.78% |
| Glioblastoma | 592 | 6.25% | 2.53% |
| Melanoma | 444 | 4.73% | 0.45% |
| Prostate Adenocarcinoma | 494 | 2.02% | 2.23% |
| mTOR | |||
| Cancer Type | Number of Cases | Mutation Frequency | Amplification Frequency |
| Melanoma | 444 | 11.94% | 0.90% |
| Endometrial Carcinoma | 586 | 10.58% | 0.85% |
| Esophagogastric Adenocarcinoma | 514 | 6.42% | 1.75% |
| Colorectal Adenocarcinoma | 594 | 6.73% | – |
| Renal Clear Cell Carcinoma | 511 | 6.07% | – |
| Non-Small Cell Lung Cancer | 1053 | 4.18% | 0.19% |
| PTEN | |||
| Cancer Type | Number of Cases | Mutation Frequency | Delation Frequency |
| Endometrial Carcinoma | 586 | 58.02% | 2.56% |
| Glioblastoma | 592 | 22.13% | 8.95% |
| Prostate Adenocarcinoma | 494 | 2.63% | 15.59% |
| Melanoma | 444 | 9.46% | 5.86% |
| Cervical Squamous Cell Carcinoma | 251 | 7.57% | 4.78% |
| Esophagogastric Adenocarcinoma | 514 | 6.03% | 4.28% |
| Invasive Breast Carcinoma | 1084 | 5.17% | 4.98% |
| Non-Small Cell Lung Cancer | 1053 | 5.60% | 4.75% |
| Sarcoma | 255 | 2.35% | 5.88% |
| Colorectal Adenocarcinoma | 594 | 5.22% | 2.36% |
| Bladder Urothelial Carcinoma | 411 | 3.89% | 3.16% |
| Ovarian Epithelial Tumor | 584 | 1.20% | 4.45% |
| Diffuse Glioma | 513 | 4.68% | 0.97% |
| Hepatocellular Carcinoma | 369 | 1.90% | 3.52% |
| Head and Neck Squamous Cell Carcinoma | 523 | 2.29% | 2.87% |
| AKT1 | |||
| Cancer Type | Number of Cases | Mutation Frequency | Amplification Frequency |
| Endometrial Carcinoma | 586 | 3.24% | 1.02% |
| Ovarian Epithelial Tumor | 584 | 3.94% | 0.17% |
| Invasive Breast Carcinoma | 1084 | 2.49% | 1.11% |
| Melanoma | 444 | 2.70% | – |
| Cervical Squamous Cell Carcinoma | 251 | 1.59% | 1.20% |
| Non-Small Cell Lung Cancer | 1053 | 0.85% | 1.71% |
| AKT2 | |||
| Cancer Type | Number of Cases | Mutation Frequency | Amplification Frequency |
| Pancreatic Adenocarcinoma | 184 | 0.54% | 7.07% |
| Endometrial Carcinoma | 586 | 3.58% | 3.57% |
| Ovarian Epithelial Tumor | 584 | 0.17% | 5.31% |
| Cervical Squamous Cell Carcinoma | 251 | 1.99% | 3.59% |
| Sarcoma | 255 | 0.39% | 3.53% |
| Non-Small Cell Lung Cancer | 1053 | 1.14% | 3.32% |
| Esophagogastric Adenocarcinoma | 514 | 2.14% | 1.17% |
| Bladder Urothelial Carcinoma | 411 | 0.97% | 2.43% |
| AKT3 | |||
| Cancer Type | Number of Cases | Mutation Frequency | Amplification Frequency |
| Invasive Breast Carcinoma | 1084 | 0.74% | 9.78% |
| Endometrial Carcinoma | 586 | 5.29% | 2.73% |
| Hepatocellular Carcinoma | 369 | 0.27% | 5.96% |
| Melanoma | 444 | 2.48% | 2.93% |
| Ovarian Epithelial Tumor | 584 | 5.65% | – |
| Non-Small Cell Lung Cancer | 1053 | 1.14% | 3.51% |
| Esophagogastric Adenocarcinoma | 514 | 1.75% | 1.36% |
| Pancreatic Adenocarcinoma | 184 | 0.54% | 2.17% |
| Colorectal Adenocarcinoma | 594 | 2.19% | 0.51% |