TABLE 3.
MIC distributions for isolates of oxacillin-resistant S. aureus and oxacillin-resistant CoNS
| Isolate (n) | Antibiotic | No. of isolates requiring each MIC (μg/ml) (% of total isolates tested)
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ≤0.06 | 0.12 | 0.25 | 0.5 | 1 | 2 | 4 | 8 | 16 | 32 | ≥64 | ||
| Oxacillin-resistant S. aureus (310) | LY333328 | 1 (0.3) | 0 | 2 (0.7) | 24 (7.7) | 184 (59.3) | 92 (29.7) | 7 (2.3) | 0 | 0 | ||
| Vancomycin | 0 | 0 | 1 (0.3) | 21 (6.8) | 241 (77.7) | 45 (14.5) | 2 (0.7) | 0 | 0 | 0 | 0 | |
| Teicoplanin | 1 (0.3) | 4 (1.3) | 29 (9.4) | 92 (29.7) | 81 (26.1) | 53 (17.1) | 27 (8.7) | 23 (7.4) | 0 | 0 | 0 | |
| Q/D | 0 | 4 (1.3) | 39 (12.6) | 118 (38.1) | 116 (37.4) | 18 (5.8) | 12 (3.9) | 2 (0.7) | 0 | 1 (0.3) | 0 | |
| Penicillin | 0 | 1 (0.3) | 1 (0.3) | 0 | 0 | 3 (1.0) | 4 (1.3) | 2 (0.7) | 299 (96.5)a | |||
| Oxacillin | 0 | 0 | 0 | 0 | 0 | 0 | 2 (0.7) | 3 (1.0) | 305 (98.4)b | |||
| Oxacillin-resistant CoNS (264) | LY333328 | 3 (1.1) | 5 (1.9) | 6 (2.3) | 22 (8.3) | 103 (39.0) | 117 (44.3) | 8 (3.0) | 0 | 0 | ||
| Vancomycin | 0 | 0 | 4 (1.5) | 2 (0.8) | 100 (37.9) | 151 (57.2) | 6 (2.3) | 1 (0.4) | 0 | 0 | 0 | |
| Teicoplanin | 1 (0.4) | 13 (4.9) | 15 (5.7) | 16 (6.1) | 18 (6.8) | 84 (31.8) | 25 (9.5) | 85 (32.2) | 0 | 4 (1.5) | 3 (1.1) | |
| Q/D | 0 | 33 (12.5) | 123 (46.6) | 59 (22.3) | 22 (8.3) | 20 (7.6) | 5 (1.9) | 2 (0.8) | 0 | 0 | 0 | |
| Penicillin | 0 | 6 (2.3) | 3 (1.1) | 6 (2.3) | 4 (1.5) | 11 (4.2) | 9 (3.4) | 35 (13.3) | 190 (72.0)c | |||
| Oxacillin | 0 | 0 | 0 | 14 (5.3) | 4 (1.5) | 6 (2.3) | 11 (4.2) | 23 (8.7) | 206 (78.0)d | |||
a
Of these, 24 isolates demonstrated penicillin MICs of 16 μg/ml and 275 isolates demonstrated penicillin MICs of >16 μg/ml.
b
Of these, 10 isolates demonstrated oxacillin MICs of 16 μg/ml and 295 isolates demonstrated penicillin MICs of >16 μg/ml.
c
Of these, 54 isolates demonstrated penicillin MICs of 16 μg/ml and 136 isolates demonstrated penicillin MICs of >16 μg/ml.
d
Of these, 23 isolates demonstrated oxacillin MICs of 16 μg/ml and 183 isolates demonstrated penicillin MICs of >16 μg/ml.