FIGURE 3.

Effect of aflatoxin B₁ on expression of genes found in the causal subnetwork for regenerative proliferation in rat liver. We analyzed gene expression data from livers of rats exposed to a single low (1 mg/kg), medium (3 mg/kg) or high (10 mg/kg) dose of aflatoxin B₁ that were sacrificed after 24 h of exposure. Expression of the gene Vhl is denoted by a hatched column, Rb1 by a black column, and Ccnd1 by a grey column in the chart. Gene expression values significantly different from controls are denoted with asterisks in the chart. Upregulated genes are denoted by a solid lined box in the subnetwork diagram and downregulated genes by dashed box.