TABLE 3.
Identified common pathways in HisCoM-SM and conventional HisCoM (q-value < 0.05). The pathways are categorized by KEGG pathway categories and KEGG pathway subcategories. The values in parenthesis are the number of pathways included in the KEGG pathway.
| KEGG pathway category | KEGG pathway subcategory | Pathway |
|---|---|---|
| Cellular Processes (3) | Cell growth and death | Ferroptosis |
| Cell motility | Regulation of actin cytoskeleton | |
| Cellular community - eukaryotes | Gap junction | |
| Environmental Information Processing (4) | Membrane transport | ABC transporters |
| Signal transduction | mTOR signaling pathway/Sphingolipid signaling pathway | |
| Signaling molecules and interaction | Neuroactive ligand-receptor interaction | |
| Genetic Information Processing (2) | Folding, sorting, and degradation | Sulfur relay system |
| Translation | Aminoacy-tRNA biosynthesis | |
| Human Diseases (9) | Drug resistance: antineoplastic | Antifolate resistance |
| Endocrine and metabolic disease | Insulin resistance | |
| Neurodegenerative disease | Amyotrophic lateral sclerosis/Parkinson disease | |
| Substance dependence | Alcoholism/Amphetamine addiction/cocaine addiction/Morphine addiction/Nicotine addiction | |
| Metabolism (31) | Amino acid metabolism | Alanine, aspartate and glutamate metabolism/Arginine and proline metabolism/Arginine biosynthesis/Cysteine and methionine metabolism/Glycine, serine and threonine metabolism/Histidine metabolism/Phenylalanine metabolism/Phenylalanine, tyrosine and tryptophan biosynthesis/Tyrosine metabolism/Valine, leucine and isoleucine biosynthesis/Valine, leucine, and isoleucine degradation |
| Biosynthesis of other secondary metabolites | Caffeine metabolism/Neomycin, kanamycin, and gentamicin biosynthesis | |
| Carbohydrate metabolism | Butanoate metabolism/Glyoxylate and dicarboxylate metabolism/Pyruvate metabolism | |
| Energy metabolism | Nitrogen metabolism | |
| Global overview maps | 2-Oxocarboxylic acid metabolism/Biosynthesis of amino acids/Carbon metabolism/Metabolic pathways | |
| Metabolism of cofactors and vitamins | Nicotinate and nicotinamide metabolism/Pantothenate and CoA biosynthesis/Porphyrin and chlorophyll metabolism/Thiamine metabolism | |
| Metabolism of other amino acids | beta-Alanine metabolism/D-Arginine and D-ornithine metabolism/D-glutamine and D-glutamate metabolism/Glutathione metabolism/Taurine and hypotaurine metabolism | |
| Nucleotide metabolism | Purine metabolism | |
| Organismal Systems (15) | Digestive system | Bile secretion/Mineral absorption/Pancreatic secretion/Protein digestion and absorption |
| Endocrine system | Estrogen signaling pathway/Insulin secretion/Prolactin signaling pathway | |
| Excretory system | Proximal tubule bicarbonate reclamation | |
| Nervous system | Dopaminergic synapse/GABAergic synapse/Glutamatergic synapse/Long-term depression/Retrograde endocannabinoid signaling/Synaptic vesicle cycle | |
| Sensory system | Taste transduction |