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. 2022 Mar 24;13:805984. doi: 10.3389/fphar.2022.805984

FIGURE 2.

FIGURE 2

Measurement of mechanical thresholds and pharmacological indexes. (A) The thresholds of von Frey mechanical stimulation. (B) 5-Hydroxytryptamine (5-HT) in the rat brainstem. (C) Calcitonin gene-related peptide (CGRP) in the rat brainstem. (D) Nitric oxide (NO) in the rat serum. (E) Nitric oxide synthase (NOS) in the rat serum. Data are expressed as mean ± S.D. *p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001.