Table 4.
Association of ART with adverse neonatal outcomes.
| Variable | SC, OR (95% CI) | ART, OR (95% CI) | p -value |
|---|---|---|---|
| Number of participants | 4,801 | 1,112 | |
| NRDS | |||
| Number of cases/total participants | 376/4,801 (7.8%) | 109/1,112 (9.8%) | |
| Model 1a | 1.00 (reference) | 1.37 (1.08,1.73) | 0.010 |
| Model 2b | 1.00 (reference) | 1.46 (1.11,1.93) | 0.008 |
| BPD | |||
| Number of cases/total participants | 124/4,801 (2.6%) | 41/1,112 (3.7%) | |
| Model 1a | 1.00 (reference) | 1.53 (1.04,2.23) | 0.029 |
| Model 2b | 1.00 (reference) | 1.44 (0.91,2.27) | 0.117 |
| ROP | |||
| Number of cases/total participants | 82/4,801 (1.7%) | 31/1,112 (2.8%) | |
| Model 1a | 1.00 (reference) | 1.65 (1.06,2.56) | 0.027 |
| Model 2b | 1.00 (reference) | 1.79 (1.06,3.05) | 0.031 |
| Neonatal anemia | |||
| Number of cases/total participants | 469/4,801 (9.8%) | 133/1,112 (12.0%) | |
| Model 1a | 1.00 (reference) | 1.36 (1.09,1.68) | 0.006 |
| Model 2b | 1.00 (reference) | 1.12 (0.87,1.45) | 0.373 |
| Birth defects | |||
| Number of cases/total participants | 577/4,801 (12.0%) | 137/1,112 (12.3%) | |
| Model 1a | 1.00 (reference) | 0.96 (0.78,1.18) | 0.665 |
| Model 2b | 1.00 (reference) | 0.98 (0.77,1.25) | 0.889 |
| Mortality | |||
| Number of cases/total participants | 74/4,801 (1.5%) | 16/1,112 (1.4%) | |
| Model 1a | 1.00 (reference) | 0.96 (0.54,1.68) | 0.876 |
| Model 2b | 1.00 (reference) | 0.98 (0.51,1.91) | 0.961 |
ART, assisted reproductive technology; SC, spontaneous conception; BPD, bronchopulmonary dysplasia; NRDS, neonatal respiratory distress syndrome; ROP, retinopathy of prematurity; OR, odds ratio.
a
Model 1: adjusted for maternal age, advanced maternal age, primiparous women, previous cesarean section, adverse pregnancy history, and prepregnancy reproductive system diseases.
b
Model 2: model 1 plus multiple pregnancies, cesarean section, placental abnormalities, premature rupture of membranes, amniotic fluid abnormalities, gestational diabetes mellitus, gestational anemia, thrombocytopenia in pregnancy, gestational hypothyroidism, and rheumatic immune disease.