Table 1.
Demographic and clinical findings in the patient groups. Data shown as median (inter-quartile range) or n (%). APOE = apolipoprotein E; ASRS = Apraxia of Speech Rating Scale; AVLT = Auditory Verbal Learning Test; DKEFS = Delis-Kaplan Executive Function System; MDS-UPDRS III = Movement Disorders Society Sponsored Revision of the Unified Parkinson’s Disease Rating Scale; MOANS = Mayo Older Americans Normative Studies; MoCA = Montreal Cognitive Assessment Battery; SUVR = standard uptake value ratio. Group-wise comparisons for continuous variables are from Analysis of Variance, followed by Tukey Honest Significant Differences. For categorical variables are from Fisher's Exact Test.
| AOS-PAA (n = 40) |
PPAOS (n = 36) |
PAA (n = 8) |
Control (n = 13) |
p value | |
|---|---|---|---|---|---|
| Female, n (%) | 19 (48%) | 21 (58%) | 5 (62%) | 9 (69%) | NS |
| Age at MRI, years | 70 (64, 74) | 71 (62, 78) | 69 (63, 75) | 58 (56, 60) | 0.002* |
| Disease duration, years | 3.2 (2.5, 4.2) | 3.8 (2.8, 5.3) | 2.1 (2.0, 2.6) | NA | 0.045† |
| Education, years | 15 (12, 16) | 16 (14, 18) | 14 (12, 16) | 14 (14, 16) | NS |
| APOE e4 carrier, n (%) | 8 (20%) | 7 (20%) | 1 (12%) | NA | NS |
| Global Aβ SUVR | 1.41 (1.30, 1.75) | 1.35 (1.31, 1.44) | 1.37 (1.32, 1.46) | 1.35 (1.32, 1.41) | NS |
| ASRS total | 20 (12, 27) | 15 (12, 20) | 4 (1, 5) | NA | <0.001‡ |
| WAB aphasia quotient | 86 (82, 93) | 98 (96, 99) | 87 (82, 90) | NA | <0.001§ |
| WAB fluency | 6 (5, 9) | 10 (9, 10) | 6 (6, 7) | NA | <0.001§ |
| Token test | 17 (12, 19) | 20 (19, 21) | 16 (13, 18) | NA | <0.001§ |
| Northwestern Anagram Test | 8 (6, 9) | 10 (9, 10) | 5 (4, 7) | NA | <0.001§ |
| MoCA | 24 (21, 25) | 28 (26, 29) | 24 (23, 24) | 25 (24, 27) | <0.001§ |
| MDS-UPDRS III | 14 (6, 21) | 12 (5, 18) | 6 (3, 9) | NA | 0.04# |
| AVLT Delayed Recall MOANS | 9 (8, 11) | 11 (10, 13) | 6 (4, 8) | NA | <0.001§ |
| Trail Making Test A MOANS | 7 (5, 10) | 8 (7, 11) | 7 (6, 10) | NA | NS |
| Trail Making Test B MOANS | 7 (4, 9) | 9 (7, 10) | 8 (6, 10) | NA | NS |
| DKEFS Card Sort MOANS | 8 (6, 10) | 12 (10, 14) | 7 (7, 9) | NA | <0.001¶ |
* Control is statistically different from AOS-PAA and PPAOS.
† PPAOS is statistically different from PAA.
‡ PAA is statistically different from AOS-PAA and PPAOS.
§ PPAOS is statistically different from AOS-PAA and PAA.
∥ All groups are statistically different from each other.
¶ PPAOS is statistically different from AOS-PAA.
# PAA is statistically different from AOS-PAA.