Table 2.
Remission rates of T2DM after metabolic surgery confirmed by randomized clinical trials
| Patients | Type | Number | Follow-up, yr | Weight-loss | End-point | Outcome | |
|---|---|---|---|---|---|---|---|
| Dixon et al. [31] | T2DM within 2 years BMI 30–40 kg/m2 | AGB vs. conventional therapy | 30 vs. 30 | 2 | 20.7% vs. 1.4% | HbA1c <6.2% | 73% vs. 13% |
| Ding et al. [32] | T2DM BMI 30–45 kg/m2 | AGB vs. ILMI | 23 vs. 22 | 1 | 13.5 kg vs. 8.5 kg | HbA1c <6.5%a | 33% vs. 23% |
| Courcoulas et al. [33] | T2DM BMI 30–40 kg/m2 | RYGB vs. AGB vs. ILMI | 21 vs. 20 vs. 20 | 1 | 27.0% vs. 17.3% vs. 10.2% | HbA1c <5.7% | 27% vs. 23% vs. 0% |
| Schauer et al. [34] | T2DM BMI 27–43 kg/m2 | RYGB vs. SG vs. ILMI | 50 vs. 50 vs. 50 | 1 | 29.4 kg vs. 25.1 kg vs. 5.4 kg | HbA1c <6.0% | 42% vs. 37% vs. 12% |
| Ikramuddin et al. [35] | T2DM BMI 30–40 kg/m2 | RYGB vs. ILMI | 60 vs. 60 | 1 | 26.1% vs. 7.9% | HbA1c <7.0% | 49% vs. 19% |
| Halperin et al. [36] | T2DM within 1 year BMI 30–42 kg/m2 | RYGB vs. ILMI | 19 vs. 19 | 1 | 5.1 kg vs. 1.4 kg | HbA1c <6.5% | 58% vs. 16% |
| Cummings et al. [37] | T2DM BMI 30–45 kg/m2 | RYGB vs. ILMI | 23 vs. 20 | 1 | 25.8% vs. 6.4% | HbA1c <6.0% | 60% vs. 6% |
| Mingrone et al. [38] | T2DM over 5 years BMI over 35 kg/m2 | BPD vs. RYGB vs. ILMI | 20 vs. 20 vs. 20 | 2 | 33.8% vs. 33.3% vs. 4.7% | HbA1c <6.5% | 95% vs. 75% vs. 0% |
T2DM, type 2 diabetes mellitus; BMI, body mass index; AGB, adjustable gastric band; HbA1c, glycosylated hemoglobin; ILMI, intensive lifestyle and medical intervention; RYGB, Roun-en-Y gastric bypass; SG, sleeve gastrectomy; BPD, bilopancreatic diversion.
a
On or off medication.