Table 1.
Comorbidities of the Charlson Comorbidity Index (CCI) in patients with a blood culture-proven infection in the ED (n=1039)
| Comorbidity | Prevalence (%) | Weights | |
| CCIoriginal | CCIupdated | ||
| Age* | 1 | 1 | |
| Diabetes mellitus† | 20.5 | ||
| Uncomplicated | 19.2 | 1 | 0 |
| End-organ damage | 1.3 | 2 | 1 |
| Liver disease‡ | 14.3 | ||
| Mild | 13.5 | 1 | 2 |
| Moderate to severe | 0.9 | 3 | 4 |
| Malignancy§ | 30.2 | ||
| Leukaemia, lymphoma, solid tumour | 17.4 | 2 | 2 |
| Metastatic solid tumour | 12.8 | 6 | 6 |
| AIDS¶ | 0.3 | 6 | 4 |
| Chronic kidney disease** | 16.3 | 2 | 1 |
| Congestive heart failure †† | 12.8 | 1 | 2 |
| Myocardial infarction‡‡ | 13.4 | 1 | 0 |
| Chronic pulmonary disease§§ | 12.9 | 1 | 1 |
| Peripheral vascular disease¶¶ | 11.6 | 1 | 0 |
| CVA or TIA*** | 13.6 | 1 | 0 |
| Dementia††† | 3.5 | 1 | 2 |
| Hemiplegia‡‡‡ | 0.3 | 2 | 2 |
| Connective tissue disease§§§ | 7.4 | 1 | 1 |
| Peptic ulcer disease¶¶¶ | 2.4 | 1 | 0 |
*Age: 1 point for each decade from 50 to 90 years of age.
†Diabetes mellitus: uncomplicated (= diabetes with medication), end-organ damage (= diabetes with retinopathy, neuropathy, nephropathy or Brittle diabetes).
‡Liver disease: mild (= cirrhosis without portal hypertension, chronic hepatitis), moderate to severe (= cirrhosis with portal hypertension, variceal bleeding).
§Malignancy: leukaemia, lymphoma or solid tumour. All initially treated in the last 5 years, excluding non-melanomatous skin cancers and in situ cervical carcinoma.
¶AIDS: AIDS (not just HIV positive).
**Chronic kidney disease: on dialysis, status post kidney transplant, uraemia, creatinine > 265 umol/L (not acute).
††Congestive heart failure: exertional or paroxysmal nocturnal dyspnea and has responded to digitalis, diuretics or afterload reducing agents.
‡‡Myocardial infarction: history of definite or probable myocardial infarction (ECG changes and/or enzyme changes).
§§Chronic pulmonary disease: symptomatic dyspnoea due to chronic respiratory conditions (including asthma).
¶¶Peripheral vascular disease: intermittent claudication, peripheral arterial bypass for insufficiency, gangrene, acute arterial insufficiency, untreated aneurysm (≥ 6cm).
***CVA or TIA: history of CVA (without hemiplegia) or TIA.
†††Dementia: chronic cognitive deficit.
‡‡‡Hemiplegia: hemiplegia or paraplegia.
§§§Connective tissue disease: systemic lupus erythematosus, polymyositis, mixed connective tissue disease, polymyalgia rheumatic, moderate to severe rheumatoid arthritis.
¶¶¶Peptic ulcer disease: history of treatment for ulcer disease or history of ulcer bleeding.
CVA, cerebrovascular accident; ED, emergency department; TIA, transient ischaemic attack.