Table 2.

Summary of genotype–phenotype analyses in predominantly adult cohorts

Analysis performed	Number of studies	Number of Patients	Unit	Pooled estimate (95% CI)	p value
Age-of-onset
G+vs G−*	17	5329	MD	−8.3 years (−9.9 to −6.6)	<0.0001
MYBPC3 vs MYH7*	10	1709	MD	8.2 years (10.9 to 5.4)	<0.0001
Multiple vs single variants*	4	636	MD	−7.0 years (−10.6 to 3.3)	0.0002
Sudden cardiac arrest
G+vs G−*	5	2184	OR	1.4 (0.9 to 2.2)	0.1
MYBPC3 vs MYH7*	6	804	OR	0.9 (0.4 to 1.9)	0.7
Multiple vs single variants	4	1778	Conflicting results
ICD implantation
G+vs G−	10	3288	OR	1.9 (1.5 to 2.4)	<0.0001
MYBPC3 vs MYH7*	6	1379	OR	1.2 (0.8 to 1.8)	0.34
Multiple vs single variants	2	379	No significant difference
Heart failure
G+vs G−, NYHA Class	8	1916	OR	1 (0.7 to 1.5)	0.81
G+vs G−, cardiac transplant	3	637	OR	1.5 (0.4 to 5.2)	0.54
MYBPC3 vs MYH7, NYHA Class*	4	341	OR	1 (0.6 to 1.9)	0.96
Multiple vs single variants, NYHA Class, cardiac transplant and other cardiac outcomes	3	370	Conflicting results
Septal reduction therapy
G+vs G−	16	4728	OR	1.1 (0.9 to 1.2)	0.46
MYBPC3 vs MYH7	12	2095	OR	1 (0.7 to 1.3)	0.82
Multiple vs single variants	3	543	No significant difference
Mortality
G+vs G−	7	2496	No significant difference in 5 of 7 studies
MYBPC3 vs MYH7	7	1654	No significant difference in 6 of 7 studies
Multiple vs single variants	3	1580		Conflicting results

*Additional studies not included in meta-analysis described in the text.

G+, genotype-positive; G−, genotype-negative; MD, mean difference.