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. 2022 Apr 6;12(4):e054347. doi: 10.1136/bmjopen-2021-054347

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Six protein markers in the NC, SCD, aMCI and AD groups. The concentrations of plasma apolipoprotein A1 (A), apolipoprotein CIII (B), apolipoprotein E (C), A-2-macroglobulin (D), complement C3 (E) and complement factor H (F) in different clinical groups are each shown in scatter plots with SD. The values of p shown were obtained following multiple linear regression using age, sex, APOE genotype and education level as covariates. Statistically significant p values are shown. aMCI, amnestic mild cognitive impairment; AD, Alzheimer’s disease; NC, normal controls; SCD, subjective cognitive decline.